Dual-Drug Delivery from Metal Organic Frameworks Using Defect Drug Loading

Abstract

This study investigates the development of Metal-Organic Framework (MOF- 808) for dual drug delivery, used the co-delivery of dichloroacetate (DCA) and carboplatin. DCA is utilized not only as a therapeutic agent but also to induce defect sites within the MOF structure to enhance the loading capacity for carboplatin. Two surface modification strategies for MOF-808 were examined: PEG-PO₃ and PEG-COOH. While PEG-PO₃ modification did not achieve the desired results, PEG-COOH modification significantly improved the MOFs performance. The PEG-COOH functionalized MOF-808 demonstrated satisfied result for drug release behaviour. These findings emphasize the effectiveness of surface modification in optimizing MOF-based dual drug delivery systems and highlight the potential of this approach for enhanced cancer treatment.