A Post-mortem Observational Study On an Anatomical Donor With Sporadic Inclusion Body Myositis

Abstract

Sporadic inclusion body myositis is a progressive muscle disorder that is characterized by muscle inflammation and degeneration. It is one of the distinctive categories of inflammatory myopathy, along with polymyositis and dermatomyositis. It is recognized as the most common severe form of idiopathic inflammatory myopathy that occurs in individuals who are over the age of 50 years. It has a distinctive pattern of selective muscle weakness and atrophy involving certain distal and proximal muscle groups. The aim of the study is to examine the histological and gross anatomical features of a postmortem donor with sporadic inclusion body myositis. This study included two postmortem donors, one with biopsy-proven sporadic inclusion body myositis, and the other was healthy individual with no history of chronic conditions, used as a control for this study. Haematoxylin and eosin staining, as well as gross dissection techniques, were used. The findings revealed that the donor with sporadic inclusion body myositis had anatomical and histological abnormalities typical of the disease, especially in the muscles of the medial and anterior compartment in the lower limbs, as well as the finger flexor muscles in the upper limbs. The results emphasise the variability of muscle progression selectiveness. However, the actual mechanism for this is not yet known, and further studies are needed to explain this.