The Effect of Bitter Melon (Momordica charantia) Juice on Blood Glucose Level and Lipid Profile in Prediabetic and Diabetic Rats

Abstract

This study aimed to evaluate the effect of bitter melon juice (BMJ) on blood glucose level and lipid profile of diabetic and prediabetic rats. Forty-two rats were separated into three groups. In the 1st group, rats (n=6) were fed on a basal diet and kept as a negative control group. In the 2nd group (Diabetic): rats (n=18) were injected with a single dose of subcutaneous injection of alloxan (120 mg/kg) to induce diabetes. After diabetes induction rats were divided into three subgroups as follows: subgroup one served as the positive control (n=6) and the second treated rat subgroups were fed on a basal diet and orally administered with 1 and 2 ml/day of BMJ, respectively. 3rd group: (Prediabetic): rats (n=18), high fat diet (HFD) group as induction of prediabetic rats. After prediabetic induction rats were divided into three subgroups as follows: subgroup one served as the positive control group and second treated rat subgroup were fed on HFD and orally administered with 1 and 2 ml/day of BMJ, respectively.