Clinical Utility of Cytokeratin in The Early Detection of Hepatocellular Carcinoma Among Hepatitis C Virus Patients

dc.contributor.advisorEl-Kassas, Mohamed
dc.contributor.authorAlhaddad, Mahdi
dc.date.accessioned2025-06-03T15:25:11Z
dc.date.issued2024
dc.description.abstractObjectives: Hepatocellular carcinoma (HCC) is a primary malignancy of the liver and a global health problem. It is often diagnosed at advanced stage where hopeless for effective therapies. Identification of more reliable biomarkers for early detection of HCC is urgently needed. Cytokeratins are a marker of hepatic progenitor cells and act as a key player in tumor invasion. Herein, we sought to develop a novel score based on the combination of cytokeratin 18 (CK18) and cytokeratin 19 (CK19) with routine laboratory tests for accurate detection of HCC. Material & Methods: Serum CK18, CK 19, α-fetoprotein, albumin and platelets count were assayed in HCC patients (75), liver cirrhosis patients (55) and healthy control (20). Areas under receiving operating curve (AUCs) were calculated and used for construction on novel score. A novel score named CK-HCC = CK 19 (%)×0.001+ CK18 (%)×0.004 + AFP (U/L)×5.4 - Platelets count (×109)/L×0.003 – Albumin (g/L)×0.27–36 was developed. CK- HCC score produces AUC of 0.919 for differentiating patients with HCC from those with liver cirrhosis with sensitivity and specificity of a cut-off 1.3 (i.e., less than 1.3 the case is considered cirrhotic, whereas above 1.3 it is considered HCC. Conclusion: CK-HCC score could replace AFP during screening of HCV patients and early detection of HCC.
dc.format.extent162
dc.identifier.urihttps://hdl.handle.net/20.500.14154/75511
dc.language.isoen
dc.publisherHelwan University
dc.subjectHepatocellular carcinoma- HCV- Cytokeratins- Diagnosis
dc.titleClinical Utility of Cytokeratin in The Early Detection of Hepatocellular Carcinoma Among Hepatitis C Virus Patients
dc.typeThesis
sdl.degree.departmentFaculty of Science
sdl.degree.disciplineBiochemistry
sdl.degree.grantorHelwan University
sdl.degree.nameMaster

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