EVALUATION OF NON-ADHERENCE IN CLINICAL TRIALS OF ANTIDEPRESSANTS FOR MAJOR DEPRESSION DISORDER: A SYSTEMATIC REVIEW AND METAANALYSIS.
Date
0022-10-03
Authors
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Journal ISSN
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Publisher
Saudi Digital Library
Abstract
Major depression disorder is a serious mental issue which affects the physical and mental
well-being of affected persons. Hence, there is a need to develop antidepressants to treat major
depression disorder. However, medicine non-adherence is a major challenge in major depression
disorder drug development. Similarly, medication adherence is an essential aspect of the success
of antidepressant development. Adherence/non-adherence data informs the interpretation of
antidepressant clinical results, reducing clinical risks and realising antidepressant benefits in
clinical trials. However, adherence prevalence is a crucial aspect of clinical research, existing
evidence points to underreporting adherence assessment methods and outcomes in published
clinical trials. Also, RCTs that report adherence measures and outcomes fail to provide adequate
methodology regarding adherence measures and outcomes. To improve the completeness and
quality of the information in antidepressant clinical trials, this research examined medication
adherence prevalence in RCTs, measures of adherence/non-adherence, and clinical and cost
impacts of non-adherence. A systematic review and meta-analysis methodology was adopted.
Meta-analysis findings affirm that medication adherence prevalence in clinical trials for
antidepressant development is 72.2%, translating to a 27.8% non-adherence level. Qualitative
findings from the studies established direct and indirect non-adherence measures of adherence,
including self-report measures and the use of questionnaires. Impacts of non-adherence include
disease relapse and recurrence (clinical impact) and increased clinical trial costs.
Keywords: Major depression disorder, Antidepressant clinical trials, Non-adherence, Adherence,
Adherence prevalence.
Description
Keywords
Keywords: Major depression disorder, Antidepressant clinical trials, Non-adherence, Adherence, Adherence prevalence.