COMPARING AND ASSESSING THE POLYGENIC PREDICTORS ACCURACY ACROSS EUROPEAN, AFRICAN AND SOUTH ASIAN ANCESTRY FOR COMMON DISEASES AND TRAITS

Abstract

An evaluation of the polygenic score's predictive accuracy and portability for common diseases (CAD and breast cancer) and traits (height and BMI) across European, African, and South Asian ancestries was conducted. Using effect sizes estimated in European individuals, and data from the UK Biobank (which includes imputed genotypes and phenotypes for 500,000 individuals). The findings revealed that the polygenic score's predictive accuracy was inadequate for African and South Asian ancestries, indicating that the score performs optimally when derived from the same ancestry it is applied to.