Jazan University
Permanent URI for this collectionhttps://drepo.sdl.edu.sa/handle/20.500.14154/215
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Item Restricted ASSOCIATION BETWEEN ANTIPSYCHOTIC DRUGS AND HEMATOLOGICAL PARAMETERS(جامعة جازان, 2025) محزري, أمجد; حملي, حسنBackground: Psychiatric and behavioral disorders significantly impact global public health, affecting individuals across all demographics. The use of antipsychotic medications, including first- and second-generation drugs, is essential in managing these conditions; however, their effects on hematological parameters remain exploring globally. This study aimed to assess and compare complete blood count (CBC) parameters in patients receiving antipsychotic medications versus healthy controls in the Jazan region, Saudi Arabia. Methods: This retrospective study was conducted at Eradah and Psychiatric Hospital in Jazan, Saudi Arabia, the region’s only specialized psychiatric facility. The study analyzed data from 413 adult psychiatric patients (male = 316, female = 97), and 200 healthy controls (male = 138, female = 62) from January to December 2024. Patient data, including demographics, clinical characteristics, and CBC parameters, were extracted from the Vida Plus system. Statistical analyses, including t-tests, Mann-Whitney tests, chi-squared tests, were performed using GraphPad Prism 8.0, with statistical significance set at P < 0.05. Results: The CBC parameters were significantly affected in patient with psychotic disorders as compared to healthy controls. In adult patients, RBC count, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular hemoglobin (MCH) were significantly lower, suggesting a higher prevalence of subclinical anemia (P < 0.05). Red cell distribution width (RDW) was elevated in patients, indicating anisocytosis. Platelet counts were comparable between groups. White blood cell (WBC) counts did not differ significantly, but adult patients showed increased absolute neutrophil and monocyte counts, reduced absolute and percentage lymphocytes (P < 0.05), and elevated basophil percentages. These findings suggest potential subclinical inflammation and immune dysregulation associated with psychiatric disorders and/or antipsychotic medication use. Conclusion: This study highlights significant hematological alterations in psychiatric patients, particularly concerning anemia and immune function dysregulation. These findings emphasize the importance of regular hematological monitoring in psychiatric populations receiving long-term antipsychotic therapy. Further research is needed to elucidate the mechanisms underlying these hematological changes and their clinical implications.0 0