Saudi Universities Theses & Dissertations
Permanent URI for this communityhttps://drepo.sdl.edu.sa/handle/20.500.14154/11
Browse
43 results
Search Results
Item Restricted Long Term Effect of COVID-19 on Pulmonary Functions, Physical Activities, Functional Capacities, and Quality of Life. A Cross-Section Study(Imam Abdulrahman Bin Faisal University, 2023) Alshammari, Maha Ata Hmoud; شنب، السيد عبد الحميدBackground: Acinetobacter baumannii, a bacterial species which demonstrates an elevated wide range, multidrug resistance to commonly prescribed antibiotics, has been linked to recent major global outbreaks, raising a major clinical concern. Its reduced antibiotic susceptibility is closely related to the acquisition of a potent carbapenemase, and/or intrinsic gene ‘’over expression’’ through insertion sequences. Hence, this study aimed at investigating the antimicrobial susceptibility and molecular mechanisms underlying β-lactam resistance in A. baumannii, isolated at an academic medical center.Methods: To understand the basis of resistance, 103 multi-drug resistant (MDR) A. baumannii isolates were collected, their antibiotic susceptibility was tested phenotypically (Vitek II), and then molecular analyses was performed, by testing a range of commonly encountered carbapenemases—OXA-51, OXA-23, NDM, VIM, and KPC.Results: All strains demonstrated pan-resistance to most of the advanced antibiotics tested, including piperacillin/tazobactam, ceftazidime, cefepime, and ciprofloxacin. Moreover, majority of isolates exhibited resistance to imipenem (98.1%) and trimethoprim (90.3%). Approximately 50% of the strains showed meropenem, amikacin, and gentamycin resistance; however, lower resistance rate to tigecycline (4.9%) was noted. Moreover, isolates contained potent carbapenemases such as the intrinsic OXA-51 (89.3%), as well as the acquired resistant genes OXA-23 (68.9%), NDM (84.5%), and VIM (88.3%). The insertion sequence element ISAba1 was only detected in 35.9% of the strains.Conclusion: Potent resistant genes known to be carried on mobile genetic elements that aid the spread of highly resistant phenotypes were observed in a majority of isolates. These findings enforce the need for vigilant infection control measures and continuous surveillance.2 0Item Restricted Assessment of Functional Independence and Community Participation in Children with Cerebral Palsy: The Caregiver Disability Burden(Imam Abdulrahman Bin Faisal University, 2022) Al-Turki, Elaf Turki Ali; Ismail, Alaa Ibrahim14 0Item Restricted Effects of smartphone addiction on cognitive function and physical activity in middle-school children: A cross-sectional study(Imam Abdulrahman Bin Faisal University, 2022) Al-Amri, Ahlam Mohammed Abdullah; Abualait, Turki Saeed22 0Item Restricted Identification of Early Neurocognitive, Neuroimaging and Neurophysiological Predictors of Learning-based Language Disabilities: A Bibliometric Analysis, Systematic Review and Meta-Analysis(Imam Abdulrahman Bin Faisal University, 2022) Alabbad, Maryam Saad; Abualait, Turki1 0Item Restricted Assessment of Motor Performance in Children with Autism Spectrum Disorder: The Relationship with Clinical Characteristics and Intelligence(Imam Abdulrahman Bin Faisal University, 2022) Al- Hussain, Jenan Mohammad; Ibrahim, Alaa2 0Item Restricted Cross-cultural Adaptation and Validation of the Arabic Version of Upper Limb Functional Index(Imam Abdulrahman Bin Faisal University, 2022) Albahrani, Yousef Abdulkarim A.; الشامي، علي متعب يحي7 0Item Restricted The Short-term Effects of Instrument-Based Mobilization Compared with Manual Mobilization for Low Back Pain: A Randomized Clinical Trial(Imam Abdulrahman Bin Faisal University, 2022) Alqassab, Fadela Habib; الشامي، علي متعب يحي13 0Item Restricted Short-term effects of dry needling in addition to standardised exercise protocol in pain and quality of life in patients with chronic mechanical neck pain(Imam Abdulrahman Bin Faisal University, 2022) Almushahhim, Muhannad Abdulrahman; نعماني، شبلي8 0Item Restricted Translation and validation of the Chronic Pain Acceptance Questionnaire (CPAQ) into Arabic(Imam Abdulrahman Bin Faisal University, 2022) Al-Arfaj, Safiah Khalied; Abdulla, Fuad Abdulrahman8 0Item Restricted Correlation of ankle dorsiflexion range of motion with lower-limb kinetic chain function and hop test performance in healthy young athletes(Imam Abdulrahman Bin Faisal University, 2022) Almansoof, Haifa Saleh; Varkeri, Shibili Nuhmani; Almuaidi, Qassim Ibrahim1 0