Mechanisms of regulation of growth and cell wall biogenesis in pathogenic mycobacteria

Abstract

Mycobacterium tuberculosis is the pathogen that causes tuberculosis, one of the most infectious diseases that claim human lives worldwide, with an estimated 1 million deaths annually. The aim of this project is to study all drrABC genes and whether they are required for PDIM translocations. To understand the role of drrABC genes and expand our understanding of lipid transport, as well as whether drrABC genes have additional roles with mmpL7 in PDIM transporter transport and whether drrABC genes have an important role in lipid efflux in PDIM which is an important virulence factor of tuberculosis bacteria in antibiotic resistance and host immune system confrontation.