SACM - Australia
Permanent URI for this collectionhttps://drepo.sdl.edu.sa/handle/20.500.14154/9648
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Item Restricted DOES THE NEW BCR::ABL ASCIMINIB (ABL001) TYROSINE KINASE INHIBITOR INDUCE PLATELET ACTIVATION, INCREASE THROMBUS FORMATION AND PROMOTE A PROTHROMBOINFLAMMATORY STATE?(Saudi Digital Library, 2026) Omar, Musab; Jackson, DeniseAbatract Background: Chronic myeloid leukaemia (CML) is driven by the BCR::ABL1 gene, leading to the development of tyrosine kinase inhibitors (TKIs) such as Imatinib, Nilotinib, and Ponatinib. However, resistance or intolerance to ATP-competitive TKIs remains a challenge for some patients. Asciminib , a novel TKI, targets the myristoyl pocket of ABL1 instead of the ATPbinding site, reducing resistance to mutations. As Asciminib is linked to thrombocytopenia, its effects on platelet activation, endothelial function, and inflammation must be studied to assess its potential to promote thrombosis. Hypothesis: We hypothesised that Asciminib may potentiate a thromboinflammatory state over time. Aim: The main objective of this study is to determine the potential of Asciminib as a monotherapy in inducing pathological responses to platelets and endothelium over time within the vasculature. Materials and Methods: This study assessed the effects of TKIs including Asciminib on platelets and thrombotic biomarkers. Washed platelets were used to measure granule secretion, thrombus formation, surface proteins, apoptosis, and viability. Plasma from Asciminib-treated CML patients was analysed using sandwich ELISA for inflammatory and platelets-endothelial biomarkers, and thrombin generation assays were performed to study coagulation. This approach combined in vitro and ex vivo methods to explore the impact of Asciminib on platelet function and thrombotic potential Results: The study shows that Asciminib does not promote platelet activation or thrombus formation. Instead, it exhibits an inhibitory effect on thrombus formation in vitro and demonstrates anti-thromboinflammatory properties in vivo. Asciminib promotes thrombin generation over time revealing an effect on secondary haemostasis. Conclusion: Asciminib does not induce a prothrombotic or proinflammatory state, which is advantageous for CML patients on treatment to avoid adverse side effects that can be life threatening. However, the potentiation of thrombin generation over time could predispose CML patients to venous thrombosis or acute ischaemic stroke, particularly in the elderly.9 0Item Restricted Supporting nutrition care in routine clinical care: Co-development of digital nutrition educational resources for multiple sclerosis management and its metabolic comorbidities(Saudi Digital Library, 2025) Allogmanny, Shoroog Mohammad A; Probst, Yasmine; Stefoska-Needham, AnitaAlthough multiple sclerosis (MS) has no cure, nutrition has the potential to delay MS-related disability progression and improve quality-of-life for people living with MS (plwMS) by managing metabolic comorbidities, some symptoms and malnutrition. Current evidence-based nutrition approaches for MS align with national dietary guidelines. However, plwMS often encounter contradictory, non-evidence-based nutrition advice, creating confusion and nutritional risk without clear guidance from healthcare professionals (HCPs). Routine MS care offers an ideal setting for supporting nutrition care, defined as practices by HCPs to improve nutritional status through screening, advice, or referral. Effective implementation requires sufficient knowledge, skills and educational resources. However, the educational resources available for HCPs remain unclear, and there is a paucity of evidence investigating the perspectives and needs of key stakeholders, namely HCPs and plwMS, regarding the integration of nutrition into routine MS care. This PhD research aimed to co-develop nutrition education resources with key stakeholders and evaluate their usability to support the integration of nutrition into routine MS care. Four interrelated studies were undertaken, guided by the Design Thinking framework (Empathising, Defining, Ideating, Prototyping, and Testing) and underpinned by principles of Participatory Action Research. It was hypothesised that nutrition-related care should be integrated into routine MS care to empower plwMS to improve their health, thereby mitigating some MS-related complications (e.g., metabolic comorbidities). Nutrition education resources may be required to support HCPs in facilitating this integration. Study 1, a scoping review of peer-reviewed (n = 7) and grey literature (n = 32), identified a scarcity of evidence-based, MS-specific nutrition education resources. Of the 13 resources addressing nutrition, only two were HCP training programs and two were patient education materials (PEMs); none were co-developed with key stakeholders. These findings informed subsequent studies. Study 2 surveyed 35 dietitians and 66 non-dietitian HCPs to examine current practices, perceptions, confidence, and resource needs related to MS nutrition care. While 73.3% reported providing nutrition advice, only 28.7% routinely screened for malnutrition. Dietitians reported significantly higher perceptions of role importance, relevance of nutrition management for MS and its symptoms, and confidence in providing nutrition advice compared with non-dietitian HCPs, though dietitians’ median confidence scores were not “very confident”. Nearly all respondents expressed a need for MS-specific nutrition education resources. Study 3 involved six focus groups with 25 plwMS to explore their experiences and needs. Qualitative analysis generated three key themes and seven subthemes: (1) nutrition guidance is overlooked in routine MS care due to HCPs prioritising medication over nutrition, resulting in the perception that plwMS are their own nutrition educators; (2) routine nutrition guidance is needed, highlighting the desire to receive meaningful MS-related nutrition information from HCPs with nutrition knowledge for MS; and (3) person-centred care is a priority, highlighting the importance of acknowledging that no one-size-fits-all approach exists for plwMS, and supporting a holistic approach to the coordination of nutrition care. Studies 1–3 informed Study 4, structured in three phases. Phase 1 included two workshops (n = 9 HCPs; n = 14 plwMS) and ten HCP interviews to understand the problem and ideate solutions. Four themes were generated: (1) addressing healthcare barriers to providing nutrition education in MS care; (2) supporting person centred nutrition communication; (3) fostering equity through accessible and inclusive MS-specific educational resources, such as an online website hosting downloadable PEMs and HCP learning materials; and (4) the integral role of the dietitian in MS care. Phase 2 developed prototypes, a clinician guide, a screening tool, and PEMs, hosted on a central website. Phase 3 tested prototype usability via interviews (18 HCPs; 15 plwMS), generating four themes: (1) clear, targeted messaging; (2) visually engaging and informative design; (3) lived experiences informing choices; and (4) trust, credibility and connection. Feedback guided resource refinements to support their adoption into MS care. Overall, this PhD research found that nutrition is overlooked in routine MS care, highlighting a clear need for its integration through nutrition education resources. Effective nutrition care for plwMS requires an individualised, person-centred approach supported by a multidisciplinary healthcare team to empower informed nutrition choices and address MS management, including metabolic comorbidities. This research led to the co-development of MS-specific, evidence-based, digitally accessible nutrition educational resources.12 0Item Restricted The Impact of Audit Data Analytics in The Relationship Between Internal and External Auditors in The Kingdom of Saudi Arabia(Saudi Digital Library, 2026) ALHARBI, MONA; DUC, PHAN; MICHAEL, KENDThe rapid advancement of technology is significantly reshaping auditing practices globally. Among these innovations, Audit Data Analytics (ADA) has emerged as a transformative tool, enhancing the capacity of auditors to analyse large datasets, detect risks, and improve decision-making. This thesis investigates the impact of ADA on the relationship between internal auditor (IA) and external auditor (EA) in the Kingdom of Saudi Arabia (KSA), a region undergoing rapid digital and economic transformation aligned with the kingdom’s “Vision 2030.” Despite the importance of the IA–EA cooperation for audit quality and efficiency, limited research has explored how emerging technologies such as ADA influence these dynamics, particularly in developing economies. Drawing upon Relational Coordination Theory (RCT), this study develops a conceptual model centred on organisational design, inter-organisational networks, and performance outcomes. The research examines how ADA affects IA attributes (competence, objectivity, quality of work), EA attributes (work style, risk assessment), and IA–EA cooperation, ultimately impacting audit effectiveness and audit fees. This study adopts a multiple methods approach employing an explanatory sequential multiple-methods design. The researcher first conducted 22 semi-structured interviews with internal and external auditors, followed by a survey receiving 107 valid responses. Findings from both interviews and survey data reveal that ADA has a strong positive influence on IA competencies. IAs have enhanced their data analytical capabilities, critical thinking, and technological skills, with many organisations recruiting specialists in business intelligence, data science, and artificial intelligence. ADA also strengthens IA objectivity by minimising human bias and allowing auditors to rely on data-driven assessments. Furthermore, audit quality has improved, as auditors are now able to perform full-population testing, leading to higher accuracy and reliability. The influence of ADA on EA attributes is more nuanced. Interviews suggest some improvements in EA work styles, such as greater precision and standardisation. However, survey results indicate that these changes are still evolving, with no statistically significant relationship yet established. Nevertheless, ADA has significantly enhanced EA risk assessment capabilities, allowing EAs to detect anomalies, reassess risks, and make more informed audit decisions. In terms of IA–EA cooperation, ADA has begun to foster stronger collaboration, although complete integration remains a work in progress. Improvements in IA outputs and increased reliability of IA work are gradually encouraging greater EA reliance. Both qualitative and quantitative findings support the view that ADA acts as a relational enabler, facilitating better communication and reducing audit redundancies. Regarding audit outcomes, the study finds that ADA adoption enhances audit effectiveness by improving audit quality, transparency, and timeliness. However, its impact on audit fees is mixed; while ADA reduces duplication and improves efficiency in some cases, the costs of technology adoption can offset potential fee reductions. In conclusion, this thesis indicates that ADA is not merely a technological tool but a catalyst for reshaping auditor relationships, enhancing audit processes, and fostering cooperation in KSA. It offers valuable insights for practitioners, policymakers, and researchers seeking to understand and leverage emerging technologies to improve audit quality in rapidly evolving economic landscapes.6 0Item Restricted Integrating Educational Data Mining and Artificial Intelligence to Enhance ICT User Satisfaction and Administrative Efficiency in Saudi Educational Institutions(Saudi Digital Library, 2026) Almaghrabi, Hamad; Soh, BenThe integration of Information and Communication Technology (ICT) in educational administration offers transformative opportunities to enhance efficiency and user satisfaction, but also presents significant challenges. Despite the potential of ICT systems to stream- line processes and support data-driven decision-making, their implementation is often hindered by fragmented infrastructures, inconsistent adoption, and limited alignment with user needs. This thesis addresses these challenges through the design and evaluation of the AI-integrated IiCE framework, developed to strengthen ICT adoption and administrative performance in educational institutions. Educational administrative environments are inherently complex, characterised by mul- tidimensional data, dynamic workflows, and overlapping responsibilities that often expose systemic inefficiencies. The proposed IiCE framework leverages predictive analytics and user-centred design principles to generate actionable insights for optimising ICT utilisa- tion. Its key objectives include identifying the determinants of user satisfaction, enhancing decision-making processes, and fostering an organisational culture that supports technolo- gical innovation and acceptance. Employing a mixed-methods research approach, this study investigates current ICT ad- option practices in Saudi educational institutions. Quantitative and qualitative analyses, incorporating stakeholder perceptions and institutional data, were conducted to uncover adoption barriers and performance gaps. Machine learning (ML) models were applied to predict user satisfaction trends, while SHAP (Shapley Additive Explanations) techniques provided interpretability by highlighting the most influential factors affecting adoption. The framework also integrates adaptive training modules, modular deployment strategies, and continuous feedback mechanisms to ensure sustainability and contextual adaptability. Grounded in Saudi Arabia’s Vision 2030 for digital transformation, the evaluation of the IiCE framework demonstrates its ability to enhance administrative workflows, optim- ise resource allocation, and strengthen stakeholder engagement. Expert validation con- firms its effectiveness in mitigating inefficiencies, promoting collaboration, and supporting evidence-based management practices. This research contributes to the fields of educational administration and ICT innova- tion by presenting an adaptable, AI-driven framework that bridges the gap between tech- nological potential and practical implementation. The findings underscore the value of advanced AI techniques in managing ICT complexity, driving user satisfaction, and im- proving institutional efficiency. Future work may extend this framework through real-time analytics, greater model interpretability, and cross-domain applications for broader educational impact4 0Item Restricted User Experience and Media Design in Saudi Digital Journalism: A Comparative Study of Migratory and Original Newspapers(Saudi Digital Library, 2025) Alkhomees, Eman Ibrahim; Bahfen, NasyaAbstract This doctoral thesis explores the relationship between interface design and user experience in Saudi digital newspapers, with a specific emphasis on the contrast between migratory platforms (originating from print) and born-digital platforms. It addresses a critical gap in digital journalism literature, where online newspapers are often treated as structurally equivalent, with limited attention given to their institutional legacies or divergent design trajectories. In the Saudi context - where digital transformation aligns closely with state-led reforms under Vision 2030- this distinction becomes particularly significant. Interface design in this setting reflects not only functional usability considerations but also deeper editorial philosophies and ideological commitments. The study is grounded in a reconceptualised framework of Media Richness Theory (MRT), wherein interface richness is articulated across five dimensions: Layout Clarity, Multimedia Integration, Interactivity, Personalisation and Customisation, and Aesthetic and Emotional Engagement. These dimensions provided a consistent analytical lens across all phases of the research. Methodologically, the study adopts a multi-phase, mixed-methods approach underpinned by a pragmatic epistemology. Phase One involves a quantitative content analysis of the front pages of ten Saudi digital newspapers (five migratory, five born-digital), systematically coding design attributes aligned with MRT. Phase Two consists of a mixed-method user experience (UX) experiment with Generation Z participants (n=18), combining behavioural metrics, think-aloud protocols, and screen-recorded task performance to capture real-time cognitive and affective responses. Phase Three employs semi-structured post-experience interviews to elicit reflective narratives concerning platform interaction, design perception, and emotional resonance. Findings from Phase One reveal significant structural divergences between platform types. Born-digital outlets exhibited stronger integration of multimedia elements, clearer visual hierarchies, and more prominent interactive affordances. Phase Two demonstrated that born-digital platforms facilitated more fluid user navigation and reduced cognitive friction, while legacy platforms often triggered frustration due to visual clutter, unclear icons, or delayed responsiveness. Interview data from Phase Three further highlighted Generation Z’s expectations for intuitive, transparent, and participatory digital environments expectations that were more consistently met by born-digital interfaces. Across all phases, the research shows that institutional origin remains a powerful determinant of interface design strategy, which in turn shapes both user cognition and emotional experience, including perceptions of usability, interactivity, and layout clarity among Generation Z users. The thesis contributes to theory by expanding Media Richness Theory into the domain of interface design in digital journalism. It also advances UX methodology by demonstrating the value of triangulating structural analysis, real-time behavioural observation, and post-interaction reflection. Practically, it offers evidence-based recommendations for Saudi and regional news organisations seeking to enhance digital engagement with younger audiences. By positioning the interface as a site of institutional meaning-making, communicative richness, and user affect, the study reaffirms the centrality of design in shaping the future of journalism in Arab digital contexts.9 0Item Restricted What Can We Learn About the Demands of Different Texts from Eye Movement Patterns for Less Proficient Readers?(Saudi Digital Library, 2026) Alruthaya, Salma; Mantei, Jessica; Kervin. Lisa; White, SoniaAustralian primary school classrooms are well stocked with authentic literature that offers stories rich in themes, topics, language, and opportunities for developing reading proficiency. Picturebooks, eBooks, novels, etc, often called “authentic” texts, are popular for read alouds, critical literacy, and supporting readers to make sense of the world. However, they are less often used for reading instruction or reading assessment. Instead, classroom reading assessment is increasingly characterised by the use of resources that are contrived to test concepts about print texts, phonic knowledge, vocabulary, etc. While these contrived texts are useful for assessing the secretarial skills of reading, they do not allow for the opportunity to understand the ways children respond to more complex text demands, such as reading across modes and making meanings from layered and complex messages. This narrowing of reading assessment resources is even more prevalent for less proficient readers, potentially delaying opportunities for developing reading proficiency, which is problematic, because a reader who is already “struggling” has no time to waste. What are the demands of these “authentic” texts? And how can we support all readers to read them? This thesis examines what eye movement evidence, captured during a common classroom reading assessment, can reveal about the underlying reading demands of authentic texts for less proficient readers. Specifically, it aims to: (1) deepen understanding of picturebook complexity; (2) examine how less proficient readers negotiate multimodal demands; and (3) generate practical implications that align text selection with student needs. These research questions guide the inquiry: • What reading strategies does the capture of readers’ eye movements reveal as they read aloud? • What information within the text do readers use or omit according to eye movements and miscue analysis? • What implications can be drawn from Eye Movement Miscue Analysis (EMMA) to guide the selection and use of resources in the teaching of reading? EMMA was chosen in this study because it brings together observable outcomes of reading (oral reading and comprehension) with real-time process data (eye movement), thereby overcoming the limitations of conventional accuracy and fluency driven assessments that mask how readers actually construct meaning, particularly in more complex texts. A mixed-methods, descriptive case study design was employed across two sequential phases. Phase One re-examined an archival EMMA dataset comprising 26 below-benchmark participants aged 7–11 years (Years 2–6), reading picturebooks classified using the Pinnell and Fountas (2007) text complexity guide. Phase One data found that, while the complexity guide supported the identification of certain reading challenges for participants, a series of unanticipated difficulties indicated the need for an expanded guide that could account for the multimodal demands in authentic literature. Phase Two focused on knowledge translation, applying Phase One insights to develop and review an Expanded Text Complexity Guide for teachers. Fourteen child participants aged 8–11 years (Years 3–6) engaged with a new picturebook. This Phase examined in particular the demands within the text generated by the multimodal elements of the book. Methodologically, the thesis establishes EMMA as a method capable of capturing the fine-grained interplay between reader and text. Substantively, it offers a research-informed Expanded Text Complexity Guide and advocates for wider instructional use of authentic texts to cultivate strategic and adaptive reading. Collectively, these contributions refine theoretical understanding of text complexity, enrich assessment practice, and equip educators with valuable, actionable insights for fostering literacy for children in an increasingly multimodal world.13 0Item Restricted Real-Time IoT Data Cleaning and Anomaly Detection Using Context-Aware Frameworks and Large Language Models(Saudi Digital Library, 2026) Alotaibi, Obaid Haylan B; Eric, Pardede; Sarath, TomyThe Internet of Things (IoT) has delivered significant benefits to various domains such as healthcare, business, and industry by generating vast amounts of data in real time. However, IoT-generated data often suffers from low quality due to issues that can significantly affect data analysis results and lead to inaccurate decision making. Enhancing the quality of real-time data streams has become a challenging task because the characteristics of IoT data make anomaly detection particularly chal lenging, which is crucial for informed decisions. Traditional IoT data cleaning tech niques primarily rely on batch processing methods, which introduce latency and fail to effectively handle real-time streaming IoT data. Many studies have proposed different techniques to overcome these challenges, such as cleaning data in real time; however, no comprehensive data cleaning framework has been proposed. This thesis proposes a comprehensive streaming data cleaning framework aimed at improving the quality of real-time data streams. Central to this framework is a real-time anomaly detection model for structured IoT data streams. The model de tects multiple types of anomalies and classifies them as either significant events or errors. Additionally, the proposed method incorporates context-awareness to further enhance detection reliability. Building upon this detection capability, the framework includes an automated repair system that addresses detected anom alies via multiple repair techniques: delete, replace, or keep, using statistical mea surements and machine learning based on anomaly classification. To enhance user decision-making, the framework integrates large language mod els for data stream cleaning, providing context-aware recommendations and sen sitivity assessments. Large language models operate locally, assisting users to dynamically refine contexts and sensitivity levels based on real-time interaction streams across diverse applications. Overall, this thesis highlights the proposed framework’s effectiveness in guiding users by providing a clear picture, thereby enhancing decision-making accuracy in real-time environments and enabling confident, real-time responses to genuine anomalies.24 0Item Restricted Are car-free lifestyles feasible in low-density, sprawling contexts? A comparison of a city in Australia and Saudi Arabia(Saudi Digital Library, 2026) Almubarak, Sufian; Pojani, DorinaThis research examines the impacts associated with adopting a car-free lifestyle among urban residents, with a particular focus on low-density, sprawling cities in Saudi Arabia and Australia. The study targets the cities of Al-Ahsa and Brisbane, conducting detailed case analyses to shed light on the key elements of daily life impacted by transportation alternatives. It examines behavioural changes related to transportation choices, adjustments in daily routines, and the diversity of transportation modes used in a car-free environment, as well as commuting patterns, communication strategies, financial impacts, and barriers faced by residents. The research uses the Transtheoretical Model of change (TTM) as a guiding theoretical framework, facilitating a nuanced exploration of the complexities involved in behavioural change. This framework is vital because it captures not only the full experiences of individuals who have successfully transitioned to a car-free lifestyle, but also partial experiences and relapses. By linking empirical observations to theoretical foundations, the study offers multidimensional research on how car-free living impacts urban residents, enriching the debate on sustainable urban living. The Methodological contributions, of this study is uniqe car-free experimental design , which deliberately chooses a matching paired design to compare the highly car-dependent Gulf context with the more well-understood and researched North American/Australian context. Examining Al-Ahsa, the study reveals that a car-free lifestyle is possible, but its limitations are limited to a small geographical area connecting adjacent neighbourhoods. Outside of these neighbourhood's, the feasibility of car-free living diminishes significantly, highlighting the need for comprehensive urban planning. The current infrastructure does not support a comprehensive public transportation system, necessitating a radical reassessment of transportation policies and investments within Al-Ahsa. To achieve a more sustainable urban environment, stakeholders must prioritize the development of transportation infrastructure that facilitates a car-free lifestyle and overcomes current constraints. All this can be achieved by relying on infrastructure that supports the sustainable use of various modes of transport. In contrast, the Brisbane analysis presents a more optimistic picture, suggesting that a car-free lifestyle is feasible and effective in the central urban area. However, the study confirms that this efficiency declines significantly the further one moves from the city centre. This finding suggests that Brisbane needs to enhance its transportation framework to increase the feasibility and convenience of sustainable travel options. In both contexts, the research identifies an urgent need to develop infrastructure that supports diverse modes of transport while promoting environmental responsibility in both the city centre and the sprawling, outlying suburbs. While the research provides valuable insights, it also reflects on the challenges associated with transitioning to a car-free lifestyle. Resistance to change can be a significant barrier, as residents may struggle to adapt their daily routines and realize the potential benefits of living without a personal car. However, through targeted interventions behavioural shifts toward sustainable transport practices can be facilitated even in short period of time. This comprehensive study of car-free living in Al-Ahsa and Brisbane reveals the complexities and multifaceted nature of urban transport policies. As cities grapple with sustainability issues, understanding the impacts of a car-free lifestyle becomes increasingly important. By combining empirical insights with theoretical frameworks, the research contributes to the critical dialogue on promoting sustainable urban living, emphasizing the need for infrastructure investments that meet diverse transport needs while promoting environmentally responsible behaviours among urban residents.10 0Item Restricted The role of IL-1R8 in TLRs and IL-1Rs signaling(Saudi Digital Library, 2026) Alenzi, Nada Hnef S; Bostjan, KobeInnate immune signaling relies on the precise assembly of receptor-adaptor complexes to initiate inflammatory responses while preventing excessive activation. Interleukin-1 receptor 8 (IL-1R8, SIGIRR) is a key negative regulator of Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) pathways. Although its intracellular TIR domain was reported to be sufficient to inhibit LPS-induced TLR4 signaling, the structural basis of this inhibition has remained unclear. This thesis aimed to elucidate the structural and functional mechanisms by which IL-1R8TIR regulates TLR signaling. Using negative-stain electron microscopy and biochemical assays, IL-1R8TIR was shown to co-assemble with MALTIR into filaments morphologically distinct from MALTIR-only assemblies. The cryo-EM structure of these filaments was determined at 4.3 Å, revealing that IL-1R8TIR subunits engage MALTIR laterally rather than through the canonical head-to-tail interfaces seen in signaling-competent TIR assemblies. Additionally, IL-1R8 subunits interact with each other via previously uncharacterized interfaces. These findings suggest that IL-1R8TIR may modulate MALTIR filament formation in either a signaling-incompetent (inhibitory) or, under as-yet-unidentified conditions, a signaling-competent manner. Complementary assays further confirmed that IL-1R8TIR disrupts TRAMTIR filament formation, extending its inhibitory role to the TRIF-dependent branch of TLR4 signaling. Collectively, this thesis provides the first structural evidence of how IL-1R8TIR engages MALTIR to form higher-order assemblies, highlighting its potential dual role in regulating TLR-mediated innate immune responses.15 0Item Restricted Designing Digital Nudging for Online Grocery Stores(Saudi Digital Library, 2026) Alsaeed, Maryam; Adam, MarcOnline supermarkets have made grocery shopping easier for customers to purchase groceries remotely. The design of the user interface (UI) of online grocery stores plays a key role in shaping users’ daily food choices. However, the complexity of information and options available in these online environments can be overwhelming. Researchers in Information Systems (IS) and Human–Computer Interaction (HCI) have begun exploring digital nudging to drive user behaviour without restricting choices. This empowers system designers to use digital nudging for healthier and more sustainable food choices in online grocery stores. This thesis explores how system designers can use digital nudges to promote healthier and more sustainable food choices in online grocery stores. To begin, we1 conduct a scoping review of 74 studies from various domains (i.e., computing, health, marketing, and psychology) that focus on digital nudging in online supermarkets. Building on the Stimulus–Organism–Response (S-O-R) model, we develop a conceptual framework that outlines the design choices, theories, and outcome variables used in this context. Following this, we conduct 30 interviews as part of a qualitative study on the expertise of three stakeholder groups: online grocery store users, healthy eating experts, and user experience design experts. Drawing on these insights, we formulate six recommendations to help online grocery store designers implement digital nudges to promote healthier food choices. We also conduct an online experiment with 332 participants, building on Reactance Theory to develop a theoretical model that explores the influence of transparency on users’ acceptability of digital nudges for healthy and sustainable food choice in an online grocery setting. Overall, this thesis demonstrates that digital nudges can influence user perceptions and nudge acceptance, particularly when designed with transparency and contextual focus, providing a starting point for future research on designing digital nudging in online grocery shopping.16 0